Publications
2021
8. Measuring ROS and redox markers in plant cells. Akter S, Khan MS, Smith EN, Flashman E. RSC Chemical Biology. 2021 https://doi.org/10.1039/D1CB00071C
7. Cell-Permeable Platinum (IV)-Lanthanide Prodrugs: Redox-Activated Luminescence and 1H Diffusion NMR Spectroscopy. Yao K, Karunanithy G, Howarth A, Thompson AL, Christensen KE, Baldwin AJ, Faulkner S, Farrer NJ, Dalton Trans. 2021 50, 8761 – 8767
6. Zap-Pano: a Photocaged pro-drug of the KDAC inhibitor panobinostat. Troelsen KS, Calder EDD, Skwarska A, Sneddon D, Hammond EM, Conway SJ. ChemMedChem. 2021 10.1002/cmdc.202100403
5. Controlling Intramolecular Interactions in the Design of Selective, High-Affinity Ligands for the CREBBP Bromodomain. Brand M, Clayton J, Moroglu M, Schiedel M, Picaud S, Bluck JP, Skwarska A, Bolland H, Chan AKN, Laurin CMC, Scorah AR, See L, Rooney TPC, Andrews KH, Fedorov O, Perell G, Kalra P, Vinh KB, Cortopassi WA, Heitel P, Christensen KE, Cooper RI, Paton RS, Pomerantz WCK, Biggin PC, Hammond EM, Filippakopoulos P, Conway SJ . J. Med. Chem. 2021 https://doi.org/10.1021/acs.jmedchem.1c00348
4. Links between the unfolded protein response and the DNA damage response in hypoxia: a systematic review. Bolland H, Ma TS, Ramlee S, Ramadan K, Hammond EM Biochem Soc Trans., 2021 18:BST20200861. doi: 10.1042/BST20200861. Online ahead of print. PMID: 34003246
3. Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor. Skwarska A, Calder EDD, Sneddon D, Bolland H, Odyniec ML, Mistry IN, Martin J, Folkes LK, Conway SJ, Hammond EM Cell Chem Biol, 2021 22:S2451-9456(21)00159-8. doi: 10.1016/j.chembiol.2021.04.004. PMID: 33910023
2020
2. Pharmacological inhibition of ATR can lead to a blockage in autophagy. E. Bowler, A. Skwarska, J. D. Wilson, S. Ramachandran, H. Bolland, A. Easton, M-S.Hwang, K. B. Leszczynska, S. J. Conway, E. M. Hammond iScience, 2020
1. Hypoxia-activated pro-drugs of the KDAC inhibitor Vorinostat (SAHA). E. D. D. Calder, A. Skwarska, I. N. Mistry, D. Sneddon, S. J. Conway,* E. M. Hammond. Tetrahedron, 2020, in press. (Invited submission in honour of Prof. Steve Davis). ChemRvix, preprint DOI: https://doi.org/10.1016/j.tet.2020.131170